HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 93/5/2406    most recent 01085.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (27) Citing Articles via Google Scholar Google Scholar Articles by Naylor, A. S. Articles by Thorlin, T. Search for Related Content PubMed PubMed Citation Articles by Naylor, A. S. Articles by Thorlin, T.

Extended Voluntary Running Inhibits Exercise-Induced Adult Hippocampal Progenitor Proliferation in the Spontaneously Hypertensive Rat

¹Department of Physiology, Sahlgrenska Academy, ²Institute of Clinical Neuroscience, and ³The Arvid Carlsson Institute for Neuroscience at the Institute of Clinical Neuroscience, Göteborg University; and ⁴Institute for Stress Medicine, Göteborg, Sweden

Submitted 15 October 2004; accepted in final form 18 December 2004

Previous work has shown that voluntary running increases cell proliferation and neurogenesis in the dentate gyrus of the adult hippocampus. Here we report that long-term running for 24 days results in a down-regulation of hippocampal progenitor proliferation to one-half the level of nonrunning controls compared with a fivefold increase in progenitor proliferation seen after 9 days of voluntary running (short-term running). The negative effects seen on proliferation after 24 days of running were prevented by restricting daily running distances (by 30–50%) during 24 days. Long-term running for 24 days increases the response of the hypothalamic-pituitary-adrenal axis, with an increase in adrenal gland weight and increased plasma corticosterone levels, as well as decreased thymus weight, indicating a stress response as a possible mediator of decreased progenitor proliferation. Furthermore, the negative effects seen on the observed stress response after 24 days of running were prevented by restricting daily running distance. Short-term running did not alter these stress parameters compared with nonrunning controls. However, it increased phosphorylated cyclic AMP response element binding protein (pCREB) in the dentate gyrus, an increase that was not seen in nonrunning controls or after 24 days of running. Taken together, these data suggest that voluntary running does not always enhance proliferation and that the decrease in progenitor proliferation seen in long-term running is possibly mediated by mechanisms involving a stress response in the animal. However, a moderate level of long-term running was able to prevent the negative stress-related changes seen in unrestricted long-term running.

This article has been cited by other articles:

				A. S. Naylor, C. Bull, M. K. L. Nilsson, C. Zhu, T. Bjork-Eriksson, P. S. Eriksson, K. Blomgren, and H. G. Kuhn From the Cover: Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain PNAS, September 23, 2008; 105(38): 14632 - 14637. [Abstract] [Full Text] [PDF]

				M. Koehl, P. Meerlo, D. Gonzales, A. Rontal, F. W. Turek, and D. N. Abrous Exercise-induced promotion of hippocampal cell proliferation requires {beta}-endorphin FASEB J, July 1, 2008; 22(7): 2253 - 2262. [Abstract] [Full Text] [PDF]