JN Miami Valley Hospital
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 93: 3165-3176, 2005. First published February 9, 2005; doi:10.1152/jn.00971.2004
0022-3077/05 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
93/6/3165    most recent
00971.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (26)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Starr, P. A.
Right arrow Articles by Turner, R. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Starr, P. A.
Right arrow Articles by Turner, R. S.

Spontaneous Pallidal Neuronal Activity in Human Dystonia: Comparison With Parkinson’s Disease and Normal Macaque

Philip A. Starr1,4, Geoff M. Rau1, Valerie Davis1, William J. Marks, Jr.2,4, Jill L. Ostrem2,4, Donn Simmons1, Nadja Lindsey3 and Robert S. Turner1,4

1Departments of Neurological Surgery, 2Neurology, and 3Nursing, University of California, San Francisco; and 4Parkinson’s Disease Research, Education, and Clinical Center at the San Francisco Veterans Affairs Medical Center, San Francisco, California

Submitted 17 September 2004; accepted in final form 3 February 2005

Dystonia is a movement disorder defined by sustained muscle contractions, causing twisting and repetitive movements and abnormal postures. To understand the abnormalities in pallidal discharge in dystonia, we have analyzed the spontaneous activity of 453 neurons sampled from the internal or external pallidum (GPi or GPe) of 22 patients with dystonia, 140 neurons from 11 patients with Parkinson’s disease (PD), and 157 neurons from two normal non-human primates (NHPs; Macacca mulatta). All recordings were performed without systemic sedation. Mean GPi discharge rate in dystonia was 55.3 ± 1.3 (SE) Hz. This was significantly lower than in the normal NHPs (82.5 ±2.5 Hz) and lower than in PD patients (95.2 ± 2.3 Hz). Mean GPe discharge rate in dystonia (54.0 ± 1.9 Hz) was lower than in the normal NHPs (69.7 ± 3.3 Hz) and was indistinguishable from that in PD patients (56.6 ± 3.5 Hz). Mean GPi discharge rate was inversely correlated with dystonia severity. GPi showed increased oscillatory activity in the 2- to 10-Hz range and increased bursting activity in both dystonia and PD as compared with the normal NHPs. Because the abnormalities in discharge patterns were similar in dystonia compared with PD, we suggest that bursting and oscillatory activity superimposed on a high background discharge rate are associated with parkinsonism, whereas similar bursting and oscillations superimposed on a lower discharge rate are associated with dystonia. Our findings are most consistent with a model of dystonia pathophysiology in which the two striatal cell populations contributing to the direct and indirect intrinsic pathways of the basal ganglia both have increased spontaneous activity.

Address for reprint requests and other correspondence: P. A. Starr, Dept. of Neurosurgery, University of California, San Francisco, 505 Parnassus Ave., 779 Moffitt, San Francisco, CA 94143 (E-mail: starrp{at}itsa.ucsf.edu)




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
M. Desmurget and R. S. Turner
Testing Basal Ganglia Motor Functions Through Reversible Inactivations in the Posterior Internal Globus Pallidus
J Neurophysiol, March 1, 2008; 99(3): 1057 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. F. Chang, R. S. Turner, J. L. Ostrem, V. R. Davis, and P. A. Starr
Neuronal Responses to Passive Movement in the Globus Pallidus Internus in Primary Dystonia
J Neurophysiol, December 1, 2007; 98(6): 3696 - 3707.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J.-L. Houeto, J. Yelnik, E. Bardinet, L. Vercueil, P. Krystkowiak, V. Mesnage, C. Lagrange, D. Dormont, J.-F. Le Bas, J.-P. Pruvo, et al.
Acute Deep-Brain Stimulation of the Internal and External Globus Pallidus in Primary Dystonia: Functional Mapping of the Pallidum
Arch Neurol, September 1, 2007; 64(9): 1281 - 1286.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R. L. Alterman, J. Miravite, D. Weisz, J. L. Shils, S. B. Bressman, and M. Tagliati
Sixty hertz pallidal deep brain stimulation for primary torsion dystonia
Neurology, August 14, 2007; 69(7): 681 - 688.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. K. H. Tang, E. Moro, N. Mahant, W. D. Hutchison, A. E. Lang, A. M. Lozano, and J. O. Dostrovsky
Neuronal Firing Rates and Patterns in the Globus Pallidus Internus of Patients With Cervical Dystonia Differ From Those With Parkinson's Disease
J Neurophysiol, August 1, 2007; 98(2): 720 - 729.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. I. Lee, L. Verhagen Metman, S. Ohara, P. M. Dougherty, J. H. Kim, and F. A. Lenz
Internal Pallidal Neuronal Activity During Mild Drug-Related Dyskinesias in Parkinson's Disease: Decreased Firing Rates and Altered Firing Patterns
J Neurophysiol, April 1, 2007; 97(4): 2627 - 2641.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
M. R. DeLong and T. Wichmann
Circuits and Circuit Disorders of the Basal Ganglia
Arch Neurol, January 1, 2007; 64(1): 20 - 24.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the The American Physiological Society.