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Computational Modeling Suggests That Response Properties Rather Than Spatial Position Determine Connectivity Between Olfactory Glomeruli

¹Department of Neurobiology and Behavior, Cornell University, Ithaca, New York; ²The Rockefeller University, New York, New York; and ³Department of Entomology, University of California, Riverside, California

Submitted 15 December 2004; accepted in final form 19 January 2005

Olfactory responses require the representation of high-dimensional olfactory stimuli within the constraints of two-dimensional neural networks. We used a computational model of the honeybee antennal lobe to test how inhibitory interactions in the antennal lobe should be organized to best reproduce the experimentally measured input-output function in this structure. Our simulations show that a functionally organized inhibitory network, as opposed to an anatomically or all-to-all organized inhibitory network, best reproduces the input-output function of the antennal lobe observed with calcium imaging. In this network, inhibition between each pair of glomeruli was proportional to the similarity of their odor-response profiles. We conclude that contrast enhancement between odorants in the honeybee antennal lobe is best achieved when interglomerular inhibition is organized based on glomerular odor response profiles rather than on anatomical neighborhood relations.

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