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J Neurophysiol 93: 3463-3478, 2005. First published February 9, 2005; doi:10.1152/jn.00794.2004
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Neural Sensitivity to Interaural Envelope Delays in the Inferior Colliculus of the Guinea Pig

Sarah J. Griffin1,2, Leslie R. Bernstein3, Neil J. Ingham1 and David McAlpine1,2

1Department of Physiology and 2The Ear Institute at University College London, London, United Kingdom; and 3Departments of Neuroscience and Surgery, University of Connecticut Health Center, Farmington, Connecticut

Submitted 4 August 2004; accepted in final form 27 January 2005

Interaural time differences (ITDs) are important cues for mammalian sound localization. At high frequencies, sensitivity to ITDs, which are conveyed only by the envelope of the waveforms, has been shown to be poorer than sensitivity to ITDs at low frequencies, which are conveyed primarily by the fine structure of the waveforms. Recently, human psychophysical experiments have demonstrated that sensitivity to envelope-based ITDs in high-frequency transposed tones can be equivalent to low-frequency fine-structure–based ITD sensitivity. Transposed tones are designed to provide high-frequency auditory nerve fibers (ANFs) with similar temporal information to that provided by low-frequency tones. We investigated neural sensitivity to ITDs in high-frequency transposed and sinusoidally amplitude modulated (SAM) tones, in the inferior colliculus of the guinea pig. Neural sensitivity to ITDs in transposed tones was found to be greater than that to ITDs in SAM tones; in response to transposed tones, neural firing rates were more modulated as a function of ITD and discrimination thresholds were found to be lower than those in response to SAM tones. Similar to psychophysical findings, ITD discrimination of single neurons in response to transposed tones for rates of modulation <250 Hz was comparable to neural discrimination of ITDs in low-frequency tones. This suggests that the neural mechanisms that mediate sensitivity to ITDs at high and low frequencies are functionally equivalent, provided that the stimuli result in appropriate temporal patterns of action potentials in ANFs.

Address for reprint requests and other correspondence: D. McAlpine, Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK (E-mail: d.mcalpine{at}ucl.ac.uk)




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