JN AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 94: 1469-1497, 2005. First published April 7, 2005; doi:10.1152/jn.00064.2005
0022-3077/05 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
94/2/1469    most recent
00064.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (27)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Roesch, M. R.
Right arrow Articles by Olson, C. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roesch, M. R.
Right arrow Articles by Olson, C. R.

Neuronal Activity Dependent on Anticipated and Elapsed Delay in Macaque Prefrontal Cortex, Frontal and Supplementary Eye Fields, and Premotor Cortex

Matthew R. Roesch and Carl R. Olson

Center for the Neural Basis of Cognition, Mellon Institute; and Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania

Submitted 19 January 2005; accepted in final form 27 March 2005

In macaque monkeys performing a memory-guided saccade task for a reward of variable size, neuronal activity in several areas of frontal cortex is stronger when the monkey anticipates a larger reward. This effect might depend on either the size or the value of the reward. To distinguish between these possibilities, we recorded from neurons in frontal cortex while controlling value through a manipulation of time rather than amount. A cue presented at the beginning of each trial, predicted the length of the delay during which the monkey would have to maintain fixation before performing a saccade and receiving a reward of fixed size. Predicting a short delay had effects closely similar to those of predicting a large reward: 1) monkeys were more motivated when working for a reward at short delay, 2) neurons tended to fire more strongly before a short delay, 3) individual neurons firing more strongly before a short delay tended also to fire more strongly before a large reward, and 4) the tendency to fire more strongly before a short delay was far more pronounced in premotor areas caudal to the arcuate sulcus than in association areas rostral to it. The association areas, in contrast, were marked by a tendency for neurons to fire more strongly at the end of the long delay. We conclude that predicting a short delay, like predicting a large reward, induces an enhancement of neuronal activity related to motivational modulation of the monkey's preparatory state.

Address for reprint requests and other correspondence: M. R. Roesch, University of Maryland School of Medicine, Department of Anatomy and Neurobiology, HSF-2, Room S251, 20 Penn Street, Baltimore, MD 21201 (E-mail: mroes001{at}umaryland.edu)




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
J. L. Pardo-Vazquez, V. Leboran, and C. Acuna
A role for the ventral premotor cortex beyond performance monitoring
PNAS, November 3, 2009; 106(44): 18815 - 18819.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Cisek, G. A. Puskas, and S. El-Murr
Decisions in Changing Conditions: The Urgency-Gating Model
J. Neurosci., September 16, 2009; 29(37): 11560 - 11571.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
N. D. Walsh and M. L. Phillips
Interacting Outcome Retrieval, Anticipation, and Feedback Processes in the Human Brain
Cereb Cortex, May 8, 2009; (2009) bhp098v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. Gregorios-Pippas, P. N. Tobler, and W. Schultz
Short-Term Temporal Discounting of Reward Value in Human Ventral Striatum
J Neurophysiol, March 1, 2009; 101(3): 1507 - 1523.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. K. Berdyyeva and C. R. Olson
Monkey Supplementary Eye Field Neurons Signal the Ordinal Position of Both Actions and Objects
J. Neurosci., January 21, 2009; 29(3): 591 - 599.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Minamimoto, G. La Camera, and B. J. Richmond
Measuring and Modeling the Interaction Among Reward Size, Delay to Reward, and Satiation Level on Motivation in Monkeys
J Neurophysiol, January 1, 2009; 101(1): 437 - 447.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Rezvani and B. D. Corneil
Recruitment of a Head-Turning Synergy by Low-Frequency Activity in the Primate Superior Colliculus
J Neurophysiol, July 1, 2008; 100(1): 397 - 411.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J.-W. Sohn and D. Lee
Order-Dependent Modulation of Directional Signals in the Supplementary and Presupplementary Motor Areas
J. Neurosci., December 12, 2007; 27(50): 13655 - 13666.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Heinzle, K. Hepp, and K. A. C. Martin
A Microcircuit Model of the Frontal Eye Fields
J. Neurosci., August 29, 2007; 27(35): 9341 - 9353.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Genovesio, S. Tsujimoto, and S. P. Wise
Neuronal Activity Related to Elapsed Time in Prefrontal Cortex
J Neurophysiol, May 1, 2006; 95(5): 3281 - 3285.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. R. Roesch and C. R. Olson
Neuronal Activity in Primate Orbitofrontal Cortex Reflects the Value of Time
J Neurophysiol, October 1, 2005; 94(4): 2457 - 2471.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the The American Physiological Society.