HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 94/6/3771    most recent 00455.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Salgado, H. Articles by Bargas, J. Search for Related Content PubMed PubMed Citation Articles by Salgado, H. Articles by Bargas, J.

A Reconfiguration of Ca_V2 Ca²⁺ Channel Current and Its Dopaminergic D₂ Modulation in Developing Neostriatal Neurons

Departamento de Biofísica, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

Submitted 3 May 2005; accepted in final form 17 August 2005

The modulatory effect of D₂ dopamine receptor activation on calcium currents was studied in neostriatal projection neurons at two stages of rat development: postnatal day (PD)14 and PD40. D₂-class receptor agonists reduced whole cell calcium currents by about 35% at both stages, and this effect was blocked by the D₂ receptor antagonist sulpiride. Nitrendipine partially occluded this modulation at both stages, indicating that modulation of Ca_V1 channels was present throughout this developmental interval. Nevertheless, modulation of Ca_V1 channels was significantly larger in PD40 neurons. -Conotoxin GVIA occluded most of the Ca²⁺ current modulation in PD14 neurons. However, this occlusion was greatly decreased in PD40 neurons. -Agatoxin TK occluded a great part of the modulation in PD40 neurons but had a negligible effect in PD14 neurons. The data indicate that dopaminergic D₂-mediated modulation undergoes a change in target during development: from Ca_V2.2 to Ca_V2.1 Ca²⁺ channels. This change occurred while Ca_V2.2 channels were being down-regulated and Ca_V2.1 channels were being up-regulated. Presynaptic modulation mediated by D₂ receptors reflected these changes; Ca_V2.2 type channels were used for release in young animals but very little in mature animals, suggesting that changes took place simultaneously at the somatodendritic and the synaptic membranes.

This article has been cited by other articles:

				L. Ferron, A. Davies, K. M. Page, D. J. Cox, J. Leroy, D. Waithe, A. J. Butcher, P. Sellaturay, S. Bolsover, W. S. Pratt, et al. The Stargazin-Related Protein {gamma}7 Interacts with the mRNA-Binding Protein Heterogeneous Nuclear Ribonucleoprotein A2 and Regulates the Stability of Specific mRNAs, Including CaV2.2 J. Neurosci., October 15, 2008; 28(42): 10604 - 10617. [Abstract] [Full Text] [PDF]

				J. T. Moyer, J. A. Wolf, and L. H. Finkel Effects of Dopaminergic Modulation on the Integrative Properties of the Ventral Striatal Medium Spiny Neuron J Neurophysiol, December 1, 2007; 98(6): 3731 - 3748. [Abstract] [Full Text] [PDF]

				H. Salgado, T. Bellay, J. A. Nichols, M. Bose, L. Martinolich, L. Perrotti, and M. Atzori Muscarinic M2 and M1 Receptors Reduce GABA Release by Ca2+ Channel Modulation Through Activation of PI3K/Ca2+-Independent and PLC/Ca2+-Dependent PKC J Neurophysiol, August 1, 2007; 98(2): 952 - 965. [Abstract] [Full Text] [PDF]

				F. Tecuapetla, L. Carrillo-Reid, J. Bargas, and E. Galarraga Dopaminergic modulation of short-term synaptic plasticity at striatal inhibitory synapses PNAS, June 12, 2007; 104(24): 10258 - 10263. [Abstract] [Full Text] [PDF]

				A. Hernandez, O. Ibanez-Sandoval, A. Sierra, R. Valdiosera, D. Tapia, V. Anaya, E. Galarraga, J. Bargas, and J. Aceves Control of the Subthalamic Innervation of the Rat Globus Pallidus by D2/3 and D4 Dopamine Receptors J Neurophysiol, December 1, 2006; 96(6): 2877 - 2888. [Abstract] [Full Text] [PDF]

				O. Ibanez-Sandoval, A. Hernandez, B. Floran, E. Galarraga, D. Tapia, R. Valdiosera, D. Erlij, J. Aceves, and J. Bargas Control of the Subthalamic Innervation of Substantia Nigra Pars Reticulata by D1 and D2 Dopamine Receptors J Neurophysiol, March 1, 2006; 95(3): 1800 - 1811. [Abstract] [Full Text] [PDF]