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J Neurophysiol 94: 4290-4299, 2005. First published August 10, 2005; doi:10.1152/jn.00480.2005
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Regulation of IPSP Theta Rhythm by Muscarinic Receptors and Endocannabinoids in Hippocampus

Christian G. Reich, Miranda A. Karson, Sergei V. Karnup, Lauren M. Jones and Bradley E. Alger

Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland

Submitted 10 May 2005; accepted in final form 4 August 2005

Theta rhythms are behaviorally relevant electrical oscillations in the mammalian brain, particularly the hippocampus. In many cases, theta oscillations are shaped by inhibitory postsynaptic potentials (IPSPs) that are driven by glutamatergic and/or cholinergic inputs. Here we show that hippocampal theta rhythm IPSPs induced in the CA1 region by muscarinic acetylcholine receptors independent of all glutamate receptors can be briefly interrupted by action potential–induced, retrograde endocannabinoid release. Theta IPSPs can be recorded in CA1 pyramidal cell somata surgically isolated from CA3, subiculum, and even from their own apical dendrites. These results suggest that perisomatic-targeting interneurons whose output is subject to inhibition by endocannabinoids are the likely source of theta IPSPs. Interneurons having these properties include the cholecystokinin-containing cells. Simultaneous recordings from pyramidal cell pairs reveal synchronous theta-frequency IPSPs in neighboring pyramidal cells, suggesting that these IPSPs may help entrain or modulate small groups of pyramidal cells.

Address for reprint requests and other correspondence: B. E. Alger, Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201 (E-mail: balger{at}umaryland.edu)




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