HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplemental Figures A corrigendum has been published All Versions of this Article: 95/4/2314    most recent 01007.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by Wicher, D. Articles by Derst, C. Search for Related Content PubMed PubMed Citation Articles by Wicher, D. Articles by Derst, C.

Differential Receptor Activation by Cockroach Adipokinetic Hormones Produces Differential Effects on Ion Currents, Neuronal Activity, and Locomotion

¹Department of Neurohormones, Saxon Academy of Sciences, Jena ² Institute of Zoology, Friedrich Schiller University, Jena ³ Institute of Animal Physiology, Philipps University Marburg, Marburg ⁴ Institute of Molecular Cell Biology, Medical Faculty of the Friedrich Schiller University, Jena ⁵ Institute of Molecular Biotechnology, Jena ⁶ Center for Anatomy, Charité Berlin, Berlin, Germany

Submitted 29 September 2005; accepted in final form 28 November 2005

Adipokinetic hormone (AKH) peptides in insects serve the endocrine control of energy supply. They also produce, however, neuronal, vegetative, and motor effects, suggesting that AKHs orchestrate adaptive behavior by multiple actions. We have cloned, for Periplaneta americana, the AKH receptor to determine its localization and, based on current measurements in neurons and heterologous expression systems, the mechanisms of AKH actions. Apart from fat body, various neurons express the AKH receptor, among them abdominal dorsal unpaired median (DUM) neurons, which release the biogenic amine octopamine. They are part of the arousal system and are involved in the control of circulation and respiration. Both the two Periplaneta AKHs activate the G_s pathway, and AKH I also potently activates G_q. AKH I and—with much less efficacy—AKH II accelerate spiking of DUM neurons through an increase of the pacemaking Ca²⁺ current. Because the AKHs are released from the corpora cardiaca into the hemolymph, they must penetrate the blood-brain barrier for acting on neurons. That this happens was shown electrophysiologically by applying AKH I to an intact ganglion. Systemically injected AKH I stimulates locomotion potently in striking contrast to AKH II. This behavioral difference can be traced back conclusively to the different effectiveness of the AKHs on the level of G proteins. Our findings also show that AKHs act through the same basic mechanisms on neuronal and nonneuronal cells, and they support an integration of metabolic and neuronal effects in homoeostatic mechanisms.

This article has been cited by other articles:

				M. W. Lorenz and G. Gade Hormonal regulation of energy metabolism in insects as a driving force for performance Integr. Comp. Biol., October 1, 2009; 49(4): 380 - 392. [Abstract] [Full Text] [PDF]

				L. A. Rosenberg, J. G. Glusman, and F. Libersat Octopamine partially restores walking in hypokinetic cockroaches stung by the parasitoid wasp Ampulex compressa J. Exp. Biol., December 15, 2007; 210(24): 4411 - 4417. [Abstract] [Full Text] [PDF]