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Neuronal Activity Related to Elapsed Time in Prefrontal Cortex

Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland

Submitted 28 September 2005; accepted in final form 11 January 2006

We studied prefrontal cortex activity during a saccade task. On each trial, one of three delay periods elapsed between the onset of a visual stimulus and its offset, which triggered a saccade. After stimulus offset, many neurons showed phasic increases in activity that depended on the duration of the preceding delay period. This delay-dependent activity varied only weakly with reaction time and instead appeared to reflect a more general aspect of elapsed time.

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