JN Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 96: 55-61, 2006. First published February 22, 2006; doi:10.1152/jn.01175.2005
0022-3077/06 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
96/1/55    most recent
01175.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (47)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Onimaru, H.
Right arrow Articles by Homma, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Onimaru, H.
Right arrow Articles by Homma, I.

Respiration-Related Rhythmic Activity in the Rostral Medulla of Newborn Rats

Hiroshi Onimaru, Yuko Kumagawa and Ikuo Homma

Department of Physiology, Showa University School of Medicine, Tokyo, Japan

Submitted 7 November 2005; accepted in final form 15 February 2006

There are at least two respiration-related rhythm generators in the medulla: the pre-Bötzinger complex, which produces inspiratory (Insp) neuron bursts, and the parafacial respiratory group (pFRG), which produces predominantly preinspiratory (Pre-I) neuron bursts. The pFRG Pre-I neuron activity has not been correlated with motor neuron activity in slice or block preparations of rostral medulla. In this study, we attempted to detect pFRG Pre-I activity as motor output in the rostral medulla. We recorded respiratory activity of the facial nerve in the brain stem–spinal cord preparation of 0- to 2-day-old rats. Facial nerve activity consisted of preinspiratory, Insp, and postinspiratory activity. Pre- and postinspiratory activity corresponded well with membrane potential trajectories of Pre-I neurons in the rostral ventrolateral medulla. In response to perfusion of 1 µM DAMGO (a µ-opiate agonist), fourth cervical ventral root (C4) Insp activity was depressed and facial nerve activity continued to synchronize with Pre-I neuron bursts. After transverse sectioning between the levels of the pre-Bötzinger complex and the pFRG, C4 Insp activity recovered within 15 min, but facial nerve activity was inhibited. When DAMGO was applied, C4 Insp activity was inhibited, and rhythmic facial nerve activity recovered. Subsequent elevation of K+ concentration reinduced C4 activity, but facial nerve activity was inhibited. Whole cell recordings in the rostral block revealed the presence of putative Pre-I neurons, the activity of which was synchronized with facial nerve activity. These results show that the rostral medulla, not including the pre-Bötzinger complex, produces Pre-I–like rhythmic activity that can be monitored as facial nerve motor output in newborn rat in vitro preparations.

Address for reprint requests and other correspondence: H. Onimaru, Department of Physiology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142, Japan (E-mail: oni{at}med.showa-u.ac.jp)




This article has been cited by other articles:


Home page
 J. Physiol.Home page
M. G. Fortuna, R. L. Stornetta, G. H. West, and P. G. Guyenet
Activation of the retrotrapezoid nucleus by posterior hypothalamic stimulation
J. Physiol., November 1, 2009; 587(21): 5121 - 5138.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
K. J. Muller, G. Tsechpenakis, R. Homma, J. G. Nicholls, L. B. Cohen, and J. Eugenin
Optical analysis of circuitry for respiratory rhythm in isolated brainstem of foetal mice
Phil Trans R Soc B, September 12, 2009; 364(1529): 2485 - 2491.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
C. Coddou, E. Bravo, and J. Eugenin
Alterations in cholinergic sensitivity of respiratory neurons induced by pre-natal nicotine: a mechanism for respiratory dysfunction in neonatal mice
Phil Trans R Soc B, September 12, 2009; 364(1529): 2527 - 2535.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
J. C. Smith, A. P. L. Abdala, I. A. Rybak, and J. F. R. Paton
Structural and functional architecture of respiratory networks in the mammalian brainstem
Phil Trans R Soc B, September 12, 2009; 364(1529): 2577 - 2587.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. P. L. Abdala, I. A. Rybak, J. C. Smith, and J. F. R. Paton
Abdominal expiratory activity in the rat brainstem\#8211;spinal cord in situ: patterns, origins and implications for respiratory rhythm generation
J. Physiol., July 15, 2009; 587(14): 3539 - 3559.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. L. Mironov, E. Skorova, N. Hartelt, L. A. Mironova, M. T. Hasan, and S. Kügler
Remodelling of the respiratory network in a mouse model of Rett syndrome depends on brain-derived neurotrophic factor regulated slow calcium buffering
J. Physiol., June 1, 2009; 587(11): 2473 - 2485.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
S. Mironov
Respiratory Circuits: Function, Mechanisms, Topology, and Pathology
Neuroscientist, April 1, 2009; 15(2): 194 - 208.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
K. Amano, M. Fujii, S. Arata, T. Tojima, M. Ogawa, N. Morita, A. Shimohata, T. Furuichi, S. Itohara, H. Kamiguchi, et al.
DSCAM Deficiency Causes Loss of Pre-Inspiratory Neuron Synchroneity and Perinatal Death
J. Neurosci., March 4, 2009; 29(9): 2984 - 2996.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Onimaru, K. Ikeda, and K. Kawakami
CO2-Sensitive Preinspiratory Neurons of the Parafacial Respiratory Group Express Phox2b in the Neonatal Rat
J. Neurosci., November 26, 2008; 28(48): 12845 - 12850.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Wittmeier, G. Song, J. Duffin, and C.-S. Poon
Pacemakers handshake synchronization mechanism of mammalian respiratory rhythmogenesis
PNAS, November 18, 2008; 105(46): 18000 - 18005.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. M. Johnson, M. E. Kinney, and L. M. Wiegel
Inhibitory and excitatory effects of {micro}-, {delta}-, and {kappa}-opioid receptor activation on breathing in awake turtles, Trachemys scripta
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2008; 295(5): R1599 - R1612.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. A. Rybak, R. O'Connor, A. Ross, N. A. Shevtsova, S. C. Nuding, L. S. Segers, R. Shannon, T. E. Dick, W. L. Dunin-Barkowski, J. M. Orem, et al.
Reconfiguration of the Pontomedullary Respiratory Network: A Computational Modeling Study With Coordinated In Vivo Experiments
J Neurophysiol, October 1, 2008; 100(4): 1770 - 1799.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. G. Guyenet
The 2008 Carl Ludwig Lecture: retrotrapezoid nucleus, CO2 homeostasis, and breathing automaticity
J Appl Physiol, August 1, 2008; 105(2): 404 - 416.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. C. Takakura, T. S. Moreira, R. L. Stornetta, G. H. West, J. M. Gwilt, and P. G. Guyenet
Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apnoeic threshold in rats
J. Physiol., June 15, 2008; 586(12): 2975 - 2991.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Giraudin, M.-J. Cabirol-Pol, J. Simmers, and D. Morin
Intercostal and Abdominal Respiratory Motoneurons in the Neonatal Rat Spinal Cord: Spatiotemporal Organization and Responses to Limb Afferent Stimulation
J Neurophysiol, May 1, 2008; 99(5): 2626 - 2640.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. A. Gray
Transcription factors and the genetic organization of brain stem respiratory neurons
J Appl Physiol, May 1, 2008; 104(5): 1513 - 1521.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. A. Hayes, J. L. Mendenhall, B. R. Brush, and C. A. Del Negro
4-Aminopyridine-sensitive outward currents in preBotzinger complex neurons influence respiratory rhythm generation in neonatal mice
J. Physiol., April 1, 2008; 586(7): 1921 - 1936.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. G. Fortuna, G. H. West, R. L. Stornetta, and P. G. Guyenet
Botzinger Expiratory-Augmenting Neurons and the Parafacial Respiratory Group
J. Neurosci., March 5, 2008; 28(10): 2506 - 2515.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K.-Z. Lee, D. D. Fuller, I-J. Lu, L.-C. Ku, and J.-C. Hwang
Pulmonary C-fiber receptor activation abolishes uncoupled facial nerve activity from phrenic bursting during positive end-expired pressure in the rat
J Appl Physiol, January 1, 2008; 104(1): 119 - 129.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. Taccola, L. Secchia, and K. Ballanyi
Anoxic persistence of lumbar respiratory bursts and block of lumbar locomotion in newborn rat brainstem spinal cords
J. Physiol., December 1, 2007; 585(2): 507 - 524.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Y. Oku, H. Masumiya, and Y. Okada
Postnatal developmental changes in activation profiles of the respiratory neuronal network in the rat ventral medulla
J. Physiol., November 15, 2007; 585(1): 175 - 186.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Ruangkittisakul, L. Secchia, T. D. Bornes, D. M. Palathinkal, and K. Ballanyi
Dependence on extracellular Ca2+/K+ antagonism of inspiratory centre rhythms in slices and en bloc preparations of newborn rat brainstem
J. Physiol., October 15, 2007; 584(2): 489 - 508.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. Onimaru, K. Ikeda, and K. Kawakami
Defective interaction between dual oscillators for respiratory rhythm generation in Na+,K+-ATPase {alpha}2 subunit-deficient mice
J. Physiol., October 1, 2007; 584(1): 271 - 284.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. S. Moreira, A. C. Takakura, E. Colombari, G. H. West, and P. G. Guyenet
Inhibitory input from slowly adapting lung stretch receptors to retrotrapezoid nucleus chemoreceptors
J. Physiol., April 1, 2007; 580(1): 285 - 300.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. J. Barnes, C.-M. Tuong, and N. M. Mellen
Functional Imaging Reveals Respiratory Network Activity During Hypoxic and Opioid Challenge in the Neonate Rat Tilted Sagittal Slab Preparation
J Neurophysiol, March 1, 2007; 97(3): 2283 - 2292.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K.-Z. Lee, D. D. Fuller, L.-C. Tung, I-J. Lu, L.-C. Ku, and J.-C. Hwang
Uncoupling of upper airway motor activity from phrenic bursting by positive end-expired pressure in the rat
J Appl Physiol, March 1, 2007; 102(3): 878 - 889.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
N. Voituron, A. Frugiere, J. Champagnat, and L. Bodineau
Hypoxia-sensing properties of the newborn rat ventral medullary surface in vitro
J. Physiol., November 15, 2006; 577(1): 55 - 68.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. L. Stornetta, T. S. Moreira, A. C. Takakura, B. J. Kang, D. A. Chang, G. H. West, J. F. Brunet, D. K. Mulkey, D. A. Bayliss, and P. G. Guyenet
Expression of Phox2b by Brainstem Neurons Involved in Chemosensory Integration in the Adult Rat
J. Neurosci., October 4, 2006; 26(40): 10305 - 10314.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2006 by the The American Physiological Society.