JN AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 96: 1569-1580, 2006. First published May 31, 2006; doi:10.1152/jn.00305.2006
0022-3077/06 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
96/3/1569    most recent
00305.2006v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (23)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Miocinovic, S.
Right arrow Articles by McIntyre, C. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miocinovic, S.
Right arrow Articles by McIntyre, C. C.

Computational Analysis of Subthalamic Nucleus and Lenticular Fasciculus Activation During Therapeutic Deep Brain Stimulation

Svjetlana Miocinovic1,2, Martin Parent3, Christopher R. Butson1, Philip J. Hahn1, Gary S. Russo4, Jerrold L. Vitek4 and Cameron C. McIntyre1,2

1Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland and 2Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio; 3Centre de Recherche Université Laval Robert-Giffard, Beauport, Quebec, Canada; 4Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, Ohio

Submitted 21 March 2006; accepted in final form 25 May 2006

The subthalamic nucleus (STN) is the most common target for the treatment of Parkinson’s disease (PD) with deep brain stimulation (DBS). DBS of the globus pallidus internus (GPi) is also effective in the treatment of PD. The output fibers of the GPi that form the lenticular fasciculus pass in close proximity to STN DBS electrodes. In turn, both STN projection neurons and GPi fibers of passage represent possible therapeutic targets of DBS in the STN region. We built a comprehensive computational model of STN DBS in parkinsonian macaques to study the effects of stimulation in a controlled environment. The model consisted of three fundamental components: 1) a three-dimensional (3D) anatomical model of the macaque basal ganglia, 2) a finite element model of the DBS electrode and electric field transmitted to the tissue medium, and 3) multicompartment biophysical models of STN projection neurons, GPi fibers of passage, and internal capsule fibers of passage. Populations of neurons were positioned within the 3D anatomical model. Neurons were stimulated with electrode positions and stimulation parameters defined as clinically effective in two parkinsonian monkeys. The model predicted axonal activation of STN neurons and GPi fibers during STN DBS. Model predictions regarding the degree of GPi fiber activation matched well with experimental recordings in both monkeys. Only axonal activation of the STN neurons showed a statistically significant increase in both monkeys when comparing clinically effective and ineffective stimulation. Nonetheless, both neural targets may play important roles in the therapeutic mechanisms of STN DBS.

Address for reprint requests and other correspondence: C. C. McIntyre, Dept. of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Ave., ND20, Cleveland, OH 44195 (E-mail: mcintyc{at}ccf.org)




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
W. Xu, G. S. Russo, T. Hashimoto, J. Zhang, and J. L. Vitek
Subthalamic Nucleus Stimulation Modulates Thalamic Neuronal Activity
J. Neurosci., November 12, 2008; 28(46): 11916 - 11924.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. D. Johnson and C. C. McIntyre
Quantifying the Neural Elements Activated and Inhibited by Globus Pallidus Deep Brain Stimulation
J Neurophysiol, November 1, 2008; 100(5): 2549 - 2563.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. D. Dorval, G. S. Russo, T. Hashimoto, W. Xu, W. M. Grill, and J. L. Vitek
Deep Brain Stimulation Reduces Neuronal Entropy in the MPTP-Primate Model of Parkinson's Disease
J Neurophysiol, November 1, 2008; 100(5): 2807 - 2818.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Guo, J. E. Rubin, C. C. McIntyre, J. L. Vitek, and D. Terman
Thalamocortical Relay Fidelity Varies Across Subthalamic Nucleus Deep Brain Stimulation Protocols in a Data-Driven Computational Model
J Neurophysiol, March 1, 2008; 99(3): 1477 - 1492.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Mallet, M. Schupbach, K. N'Diaye, P. Remy, E. Bardinet, V. Czernecki, M.-L. Welter, A. Pelissolo, M. Ruberg, Y. Agid, et al.
Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior
PNAS, June 19, 2007; 104(25): 10661 - 10666.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Maltete, N. Jodoin, C. Karachi, J. L. Houeto, S. Navarro, P. Cornu, Y. Agid, and M. L. Welter
Subthalamic Stimulation and Neuronal Activity in the Substantia Nigra in Parkinson's Disease
J Neurophysiol, June 1, 2007; 97(6): 4017 - 4022.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2006 by the The American Physiological Society.