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Not by Spikes Alone: Responses of Coordinating Neurons and the Swimmeret System to Local Differences in Excitation

Section of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, California

Submitted 2 June 2006; accepted in final form 10 October 2006

Swimmeret coordinating neurons in the crayfish CNS collectively encode a detailed cycle-by-cycle report on features of the motor output to each swimmeret. This information coordinates the motor output that drives swimmeret movements. To see how coordinating neurons responded to forced changes in intersegmental phase, we used a split-bath, repeated-measures experimental design to expose different regions of isolated abdominal nerve cords to different levels of excitation. We present a quantitative description of the firing of power-stroke (PS) motor units and two kinds of coordinating interneurons, ASC_E and DSC, recorded simultaneously from each swimmeret ganglion under uniform and nonuniform excitation. When anterior and posterior ganglia were excited differently, several parameters of the swimmeret motor pattern were affected. Strengths of PS bursts in each ganglion were determined by local excitation. The phase of PS bursts in neighboring ganglia changed at the excitation boundary. Coordinating neurons from the two ganglia closest to the excitation boundary were most affected by nonuniform excitation. ASC_E neurons tracked the timing and duration of each PS burst in their home ganglion, but did not follow changes in PS burst strength. DSC neurons changed the duration, phase, and number of spikes per burst. We propose two models to explain these results. First, the period expressed under nonuniform conditions is the sum of local intersegmental latencies and these latencies are determined by local excitation. Second, the phase change at the excitation boundary is determined by local modulation of the targets of the intersegmental coordinating neurons, not by modulation of the coordinating neurons themselves.

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