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J Neurophysiol 97: 2802-2811, 2007. First published January 24, 2007; doi:10.1152/jn.00918.2006
0022-3077/07 $8.00

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Contextual Interaction of GABAergic Circuitry With Dynamic Synapses

Department of Physics, Washington University, St. Louis, Missouri

Submitted 29 August 2006; accepted in final form 19 January 2007

Visual context shapes human perception, yet our understanding of this phenomenon in terms of synaptic circuitry is still rudimentary. Our in vitro experiments with avian tectum reveal two distinct GABAergic pathways that mediate the spatiotemporal tectal interaction of retinal inputs. One pathway mediates postsynaptic lateral inhibition. The other pathway interacts with the synaptic depression of retinotectal synapses. Simulations of an experimentally constrained model including the two pathways reproduce the observed avian tectum wide-field neuron's sensitivity to small and moving stimuli, while being insensitive to whole-field motion.