HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 97/6/4258    most recent 01180.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Wang, W. Articles by Moran, D. W. Search for Related Content PubMed PubMed Citation Articles by Wang, W. Articles by Moran, D. W.

Motor Cortical Representation of Position and Velocity During Reaching

¹Department of Biomedical Engineering and ²Department of Neurobiology, Washington University in St. Louis, St. Louis, Missouri

Submitted 6 November 2006; accepted in final form 13 March 2007

This study examines motor cortical representation of hand position and its relationship to the representation of hand velocity during reaching movements. In all, 978 motor cortical neurons were recorded from the proximal arm area of rostral motor cortex. The results demonstrate that position and velocity are simultaneously encoded by single motor cortical neurons in an additive fashion and that the relative weights of the position and velocity signals change dynamically during reaching. The two variables—hand position and hand velocity—are highly correlated in the standard center-out reaching task. A new reaching task (standard reaching) is introduced to minimize these correlations. Likewise, a new decoding method (indirect OLE) was developed to analyze the data by simultaneously decoding both three-dimensional (3D) hand position and 3D hand velocity from correlated neural activity. This method shows that, on average, the reconstructed velocity led the actual hand velocity by 122 ms, whereas the reconstructed position signal led the actual hand position by 81 ms.

This article has been cited by other articles:

				S. J. Sober, M. J. Wohlgemuth, and M. S. Brainard Central Contributions to Acoustic Variation in Birdsong J. Neurosci., October 8, 2008; 28(41): 10370 - 10379. [Abstract] [Full Text] [PDF]

				W. Truccolo, G. M. Friehs, J. P. Donoghue, and L. R. Hochberg Primary Motor Cortex Tuning to Intended Movement Kinematics in Humans with Tetraplegia J. Neurosci., January 30, 2008; 28(5): 1163 - 1178. [Abstract] [Full Text] [PDF]