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J Neurophysiol 97: 4386-4389, 2007. First published March 28, 2007; doi:10.1152/jn.01228.2006
0022-3077/07 $8.00
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Persistent Synaptic Activity Produces Long-Lasting Enhancement of Endocannabinoid Modulation and Alters Long-Term Synaptic Plasticity

Ping Jun Zhu and David M. Lovinger

Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland

Submitted 22 November 2006; accepted in final form 20 March 2007

Learning and memory are thought to involve activity-dependent changes in synaptic efficacy such as long-term potentiation (LTP) and long-term depression (LTD). Recent studies have indicated that endocannabinoid-dependent modulation of inhibitory transmission facilitates induction of hippocampal LTP and that endocannabinoids play a key role in certain forms of LTD. Here, we show that repetitive low-frequency synaptic stimulation (LFS) produces persistent up-regulation of endocannabinoid signaling at hippocampal CA1 GABAergic synapses. This LFS also produces LTD of inhibitory synapses and facilitates LTP at excitatory, glutamatergic synapses. These endocannabinoid-mediated plastic changes could contribute to information storage within the brain.

Address for reprint requests and other correspondence: D. M. Lovinger, Lab. for Integrative Neuroscience, NIH/NIAAA, 5625 Fishers Lane, Rm. TS-28, Bethesda, MD 20892-9411 (E-mail: lovindav{at}mail.nih.gov)




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