JN Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 98: 1820-1826, 2007. First published July 11, 2007; doi:10.1152/jn.01158.2006
0022-3077/07 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
98/3/1820    most recent
01158.2006v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rosa, E. F.
Right arrow Articles by Oliveira, M. G. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rosa, E. F.
Right arrow Articles by Oliveira, M. G. M.

REPORT

Oxidative Stress Induced by Intense and Exhaustive Exercise Impairs Murine Cognitive Function

Eloi F. Rosa1, Shirley Takahashi2, Jeannine Aboulafia1, Viviane L. A. Nouailhetas1,* and Maria G. M. Oliveira2,*

1Departments of Biophysics and 2Psychobiology, Universidade Federal de São Paulo/Escola Paulista de Medicina, São Paulo, Brazil

Submitted 31 October 2007; accepted in final form 28 June 2007

It has been shown that exercise is helpful against brain disorders. However, this may not be true for intense exercise (IE). Because it is easy to misadjust exercise intensity with physical condition, it is essential to know the effects of IE on cognitive process because it may have important consequences on people skills and work skills. We investigated the effects of IE on male C57Bl/6 mice, 3-mo-old, undergoing 10 days of intense and exhaustive running program on cognition and its possible relationship with brain oxidative stress. Cognition was evaluated by three different cognitive tests: passive avoidance task, contextual fear conditioning, and tone fear conditioning, performed 24 h after the last exercise session. Brain oxidative stress was evaluated by lipid peroxidation and protein oxidation. There was a remarkable memory reduction of exercised animals in comparison with the control group, associated with increase in the brain oxidative stress, with no alterations in shock sensitivity, locomotion and anxiety parameters. Concurrent vitamin C and E supplementation fully prevented the memory decrement induced by IE and partially recovered both the increased the brain lipid peroxidation and the protein oxidation. In conclusion, IE-induces a high index of brain oxidative stress and impairs memory in murine model that was prevented by vitamin C and E supplementation.

Address for reprint requests and other correspondence: M.G.M. Oliveira, Dept. of Psychobiology, Universidade Federal de São Paulo/Escola Paulista de Medicina, Rua Napoleão de Barros, 925, 04024002 São Paulo, SP, Brazil (E-mail: mgabi{at}psicobio.epm.br)




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
E. F. Rosa, R. F. Ribeiro, F. M. T. Pereira, E. Freymuller, J. Aboulafia, and V. L. A. Nouailhetas
Vitamin C and E supplementation prevents mitochondrial damage of ileum myocytes caused by intense and exhaustive exercise training
J Appl Physiol, November 1, 2009; 107(5): 1532 - 1538.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2007 by the The American Physiological Society.