Neuronal integration and the depolarizing effects of axonal GABAA receptors

Thomas J. Younts, Sachin Makani

Abstract

Despite their presence throughout the central nervous system, the impact of axonally expressed gamma-amino-butyric acid type-A receptors (GABAARs) on neuronal signaling is just beginning to be understood. A recently published article (Pugh JR and Jahr CE, J Neurosci 31: 565–574, 2011) tackled this important issue by investigating GABAAR-mediated function in axons of cerebellar granule cells. The results of Pugh and Jahr indicate parallel fiber GABAARs enhance neurotransmitter release probability and boost axonal and somatic excitability.

  • GABAA receptor
  • axon
  • excitability
  • release probability
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