Angelman syndrome is a neurodevelopmental disorder characterized by mental retardation, ataxia, and unusually happy affect. The hippocampal pyramidal cells of Angelman syndrome model mice have altered intrinsic membrane properties, which Kaphzan et al. (2013) demonstrate can be corrected by genetic reduction of the α1-subunit of the sodium-potassium ATPase. Intriguingly, this manipulation also restores hippocampal LTP and learning. In this Neuro Forum, we discuss translational implications of this work and remaining questions left in its wake.
- Angelman syndrome
- sodium-potassium ATPase
- intrinsic excitability
- long term potentiation
- Copyright © 2013, Journal of Neurophysiology