Extensive research over the past decades about the multifaceted roles of brain astrocytes led to the suggestion that the signals observed with functional neuroimaging might primarily reflect astrocytic rather than neuronal activity. The basis for this paradigm-shifting concept was the evidence for an involvement of astrocytes in the control of local cerebral blood flow through intracellular Ca2+ signaling. Here I discuss new important experimental findings obtained by Jego et al. (J Cereb Blood Flow Metab, 34:1599-1603, 2014) as well as other closely related studies published recently, prompting to a dismissal of substantial astrocytic contribution in functional neuroimaging.
- neurovascular coupling
- astrocytic Ca2+ signaling
- Copyright © 2014, Journal of Neurophysiology