Parkinson's disease (PD) is a common neurodegenerative disorder associated with motor and cognitive impairments. The mechanisms underlying the pathophysiology and treatments have traditionally focused on basal ganglia-thalamo-cortical pathways due to striatal dopamine loss, but more recent evidence has highlighted the role of the cerebellum. Here we review evidence from neuroimaging and non-invasive brain stimulation that demonstrate altered cerebellar activity in PD may be both a pathophysiological and compensatory mechanism depending on dopaminergic medication and symptoms.
- parkinson's disease
- brain stimulation
- functional connectivity
- Copyright © 2015, Journal of Neurophysiology