Table 1.

Regional activations and deactivations specific to the picture of the beloved rejecter compared to a picture of a familiar, neutral acquaintance

Brain RegionxyzPxyzP
    Ventral tegmental area−0.5−16−9.022−16−9.05
    Ventral striatum* (Accumbens core/vGP)116−6.002
    Ventral striatum* (Accumbens core)610−4.001
    Ventral striatum* Putamen−217−11.001217−11.003
    Middle orbitofrontal cortex−2831−16.053733−12.03
    Ventrolateral prefrontal cortex4037−9.002
    Lateral ventral sulcus−257−15.02
    Medial prefrontal cortex−2648.03
    Dorsolateral prefrontal cortex−423216.01
    Middle frontal gyrus30823.001
    Anterior cingulate−104016.0473816.02
    Posterior cingulate−6−5228.02
    Retrosplenial cingulate−12−4010.01
    Anterior insula26197.05
    Posterior insula−46−84.03
    Angular gyrus/sulcus44−4826.0001
    Posterior ventral pallidum−20−80.02
    Anterior dorsolateral striautm−201712.04
    Orbitofrontal cortex1934−6.01
  • Region of interest analysis, false discovery rate (FDR) multiple comparison correction. Coordinates are at the maximum value for the cluster, which may be elongated in any direction. All clusters were 15 voxels or greater. x,y,z: MNI coordinates; vGP, ventral globus pallidus.

  • * Different from happily in love (Aron et al. 2005a P < 0.01).