Table 1.

Effects of 48 h in vivo 3α,5β-THP administration on mIPSC characteristics of pyramidal cells in CA1 hippocampus

Control48 h of 3α,5β-THP
10–90% Rise time (ms)0.85 ± 0.040.78 ± 0.12
τw(35°)3.42 ± 0.452.66 ± 0.32*
τw(27°)11.6 ± 2.18.23 ± 1.65*
Monoexponential τ (ms)3.3 ± 0.632.84 ± 0.46
Biexponential τfast(ms)0.9 ± 0.160.5 ± 0.12*
(%)(38 ± 6.7)(58 ± 11.1)
τslow(ms)5.2 ± 0.55.0 ± 1.2
Percent of mIPSCs with a biexponential decay1038*
mIPSC frequency (Hz)12.5 ± 4.511.2 ± 3.1
  • Unless otherwise indicated, recordings were carried out at 35°C (n = 1,800/group, 35°C; n = 2,000/group, 27°C; representative of 80–100 mIPSCs/cell, 20–25 cells/group, 6-10 animals/group.) *P < 0.05 vs. control values.