Table 2.

Effects of partial substitution of extracellular Na+ with Li+ or choline on the main electrophysiological parameters of IB neurons

ControlLiClControlCholine-Cl
AP
 Slope, V/s315.4  ±  22.3278.4  ±  18.2* 295.4  ±  25.6199.0  ±  14.6
 Amplitude, mV114.6  ±  6.8106.0  ±  4.7* 109.5  ±  4.093.8  ±  5.7
 Repolarization, V/s115.6  ±  10.380.4.5 ± 11.3 99.3  ±  9.157.2  ±  13.2
 Duration, ms2.1  ±  0.22.7  ±  0.1 2.5  ±  0.12.9  ±  0.2
RIN, MΩ37.7  ±  3.338.8  ±  3.9* 43.2  ±  4.548.7  ±  6.9*
τm, ms16.7  ±  4.413.8  ±  2.4* 13.8  ±  2.321.2  ±  3.4*
Postburst AHP
 Amplitude, mV4.6  ±  0.33.5  ±  0.5 5.1  ±  0.63.2  ±  0.5
 Duration, ms139.0  ±  24.1125.7  ±  16.6* 125.7  ±  16.6177.4  ±  18.0*
 Area, mV × ms334.2  ±  21.9274.2  ±  27.5 356.6  ±  28.3193.8  ±  48.4
Posttrain AHP
 Amplitude, mV10.6  ±  0.96.4  ±  1.0 9.7  ±  0.34.6  ±  1.5
 Duration, ms173.0  ±  12.4156.0  ±  12.5* 218.6  ±  34.6219.0  ±  35.6*
 Area, mV × ms834.2  ±  98.5448.6  ±  75.8 1399.8  ±  357.4760.1  ±  238.1
  • Values are means ± SE; number of neurons for LiCl was 6 and for choline-Cl was 5. Control solution was the low-Ca2+ ACSF (artificial cerebrospinal fluid) LiCl (40 mH) and choline-Cl (40 mH) replaced equimolar concentrations of NaCl in the same low-Ca2+ ACSF. AP, action potential; AHP, afterhyperpolarization.

  • *  Not significantly different from control.

  •  Significantly different from control,P < 0.05.