table 1.

Biophysical properties of CA1 neurons recorded from old male F 344 rats

IR, MΩ RMP Spike Amplitude
Control (19) 62.3 ± 8.45 -64 ± 1.48 79.7 ± 0.38
DMSO (4) 51.3 ± 9.84 -62 ± 2.63 80.0 ± 1.16
CPA (5) 49.4 ± 10.5 -65 ± 0.58 80.0 ± 0.89
Ryanodine (5) 60.6 ± 9.76 -65 ± 2.76 80.4 ± 0.75
CPA + BK (3) 55.0 ± 15.4 -62 ± 2.19 82.7 ± 1.76
MCPG (3) 48.33 ± 3.84 -63 ± 0.58 82.0 ± 0.0
  • Values are mean ± SE. RMP, resting membrane potential; IR, input resistance; CPA, Cylopiazonic acid; BK, Bay K8644; MCPG, (s)- -methyl-4-carboxyphenylglycine. RMP and spike amplitude values are in mV. Numbers in parentheses indicate number of cells for each condition. In some cases, the same cell was recorded under control conditions and following treatment.