The person using APS Journals Online may view, reproduce or store copies of articles comprising the journal provided that the articles are used only for their personal, non-commercial use. Uses beyond that allowed by the "Fair Use" limitations (sections 107 and 108) of the U.S. Copyright law require permission of the publisher.
For permissions to copy beyond that permitted by the U.S. Copyright Law and for reprints, contact the Copyright Clearance Center. The fee code for users of the Transactional Reporting Service appears in each abstract and full text article.
Any uses and or copies of this Journal in whole or in part must include the customary bibliographic citation, including author attribution, date, article title, the name of the APS Online Journal, and its URL and MUST include a copy of the copyright notice.
Personal accounts and/or passwords may not be shared.
Disclaimer: The statements and opinions contained in the articles published in the journals of the American Physiological Society are solely those of the individual authors and contributors and not of the American Physiological Society. The appearance of advertisements in the journal is not a warranty, endorsement, or approval of the products or their safety. The American Physiological Society disclaims responsibility for any injury to persons or property resulting from any ideas or products referred to in any article or advertisement.
Cover: Multiregional Brain-on-a-Chip in vitro model. Neurons (green) from different brain regions (here prefrontal cortex, left, and amygdala, right) are restricted to distinct areas, but are connecting controllably to the other brain region through axons which are guided by microcontact printed lines. This is a zoom in image from the entire brain-on-a-chip model, which consists of three brain regions. This multiregional brain-on-a-chip is electrically active and reacts to drug applications in a brain region dependent way. Astrocytes are labelled in red. The smallest distance between the different brain areas is 1 mm. From Dauth S, Maoz BM, Sheehy SP, Hemphill MA, Murty T, Macedonia MK, Greer AM, Budnik B, Parker KK. Neurons derived from different brain regions are inherently different in vitro: a novel multiregional brain-on-a-chip. J Neurophysiol 117: 1320 –1341, 2017; doi:10.1152/jn.00575.2016.